University of Edinburgh researchers hopeful cholesterol drug in infancy could prevent learning problems.
Children with an inherited form of intellectual disability and autism could be helped by taking a medicine commonly used to lower cholesterol early in life, according to researchers at the University of Edinburgh’s Patrick Wild Centre and Simons Initiative for the Developing Brain.
The cholesterol drug – called lovastatin – corrected learning and memory problems in rats with a form of Fragile X Syndrome, tests revealed, and researchers are hopeful learning problems in children with Fragile X might be prevented by a similar treatment in early life. One of the most common genetic causes of intellectual disability, Fragile X syndrome is often associated with autism and attention deficit and hyperactivity disorder (ADHD). Many affected individuals also have seizures.
Statins – including lovastatin – are widely prescribed to both children and adults to control high blood cholesterol and to reduce the risk of heart disease. Rats were treated with lovastatin for four weeks during infancy but the benefits persisted for months afterwards.
The condition occurs when a particular gene is disrupted, leading to altered communication between brain cells. Previous studies in mice and rats have shown that this disruption can be treated with drugs, but it was not known how long treatment might be effective for.
“Children with Fragile X Syndrome need special education and, although some will live semi-independently, most require some form of lifelong support,”says Professor Peter Kind, director of the Patrick Wild Centre and Simons Initiative for the Developing Brain at the University of Edinburgh. We have found that early intervention for a limited period during development can lead to persistent beneficial effects, long after treatment ends, in a rat model of Fragile X Syndrome. Our future experiments will focus on whether there is a critical time-window during development when treatment is more effective.”
Researchers at the university studied rats with a genetic alteration similar to that found in people with Fragile X syndrome that have problems completing certain memory tasks when compared with typical rats.
Treatment with lovastatin between five and nine weeks of age – the precise window when they are developing the memory abilities – restored normal development in the rats. The animals were able to complete the memory tasks more than three months after treatment ended, indicating the effects of the drug were long-lasting.
Children with Fragile X Syndrome are usually diagnosed around the age of three, typically because they are late in learning to speak. Genetic tests have enabled earlier diagnosis, which raises the possibility of starting treatments sooner. Current medications help manage specific symptoms – such as hyperactivity and seizures – but there are not yet any treatments that tackle the underlying brain changes leading to Fragile X syndrome.
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